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Updated: Oct 9, 2025

In Vitro Synthesis of Modified mRNA for Induction of Protein Expression in Human Cells
Published on: November 13, 2014
Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic
Dana Elkhalifa1, Menatallah Rayan2, Ahmed T Negmeldin3
1Department of Pharmacy, Aspetar Orthopedic and Sports Medicine Hospital, Doha, Qatar.
Abstract:
Chemically modified mRNA represents a unique, efficient, and straightforward approach to produce a class of biopharmaceutical agents. It has been already approved as a vaccination-based method for targeting SARS-CoV-2 virus. The COVID-19 pandemic has highlighted the prospect of synthetic modified mRNA to efficiently and safely combat various diseases. Recently, various optimization advances have been adopted to overcome the limitations associated with conventional gene therapeutics leading to wide-ranging applications in different disease conditions. This review sheds light on emerging directions of chemically modified mRNAs to prevent and treat widespread chronic diseases, including metabolic disorders, cancer vaccination and immunotherapy, musculoskeletal disorders, respiratory conditions, cardiovascular diseases, and liver diseases.
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