Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Radiation induced inversions in human somatic cells.

B Dutrillaux, L Sabatier, W Al Achkar

Annales De Genetique

|January 1, 1986

Summary

Ionizing radiation exposure, particularly above 0.5 Gy, significantly increases the frequency of peri- and paracentric inversions. Pericentric inversions occur more often, suggesting non-random chromosomal reassociations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Y-chromosome disomy and trisomy in scarabaeid and cerambycid beetles.

Cytogenetic and genome research·2010

Same author

Chromosome polymorphism and Fanconi-like instability in the scarabaeid beetle Macraspis tristis from Guadeloupe.

Cytogenetic and genome research·2009

Same author

Sex chromosome rearrangements in Polyphaga beetles.

Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation·2009

Same author

High chromosomal polymorphism and heterozygosity in Cyclocephala tridentata from Guadeloupe: chromosome comparison with some other species of Dynastinae (Coleoptera: Scarabaeidae).

Cytogenetic and genome research·2008

Same author

X-Y-autosome translocation, chromosome compaction, NOR expression and heterochromatin insulation in the Scarabaeid beetle Dynastes hercules hercules.

Cytogenetic and genome research·2007

Same author

Nucleolus and chromosome relationships at pachynema in four Scarabaeoidea (Coleoptera) species with various combinations of NOR and sex chromosomes.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology·2007

Area of Science:

Cytogenetics
Radiation Biology
Genetics

Background:

Chromosomal inversions are structural rearrangements with implications for genetic stability.
Ionizing radiation is known to induce DNA damage, including chromosomal aberrations.

Purpose of the Study:

To analyze the induction and patterns of peri- and paracentric inversions caused by various ionizing radiation types.
To investigate the dose-response relationship and distribution of these inversions.

Main Methods:

Analysis of chromosomal inversions (peri- and paracentric) induced by gamma rays, alpha-rays, neutron beams, and neon beams.
Dose-response analysis for radiation doses >= 0.5 Gy.
Comparison of inversion frequencies and distribution patterns.

Related Experiment Videos

Main Results:

Inversion frequencies increase significantly at radiation doses of 0.5 Gy and above.
Pericentric inversions are 3-4 times more frequent than paracentric inversions.
Identical inversions are recurrently induced, some mirroring those found in human cytogenetics and primate chromosomes.

Conclusions:

Chromosomal breakage and reassociation following radiation exposure appear to follow non-random patterns.
The number of breakages correlates with chromosome length, leading to a limited set of reassociation combinations.