Related Experiment Video
Updated: Jul 4, 2026
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
A descriptive study on multisystem inflammatory syndrome in children in a single center in West Michigan
Jonathan Shabab1, Allysen Dubisky2, Ambaris Singh1
1Spectrum Health Helen DeVos Children's Hospital/Michigan State University Pediatric Residency Program, Grand Rapids, MI, USA.
Background:
Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare hyperinflammatory condition that occurs following SARS-CoV-2 infection. There is a paucity of research describing risk factors, optimal management, and outcomes of this life-threatening condition.
Methods:
This is a case series of 26 patients diagnosed with MIS-C in a West Michigan pediatric tertiary care center from April 2020 to February 2021. We describe the clinical, imaging, and laboratory characteristics of these patients and detail their treatments and outcomes with comparisons between Pediatric Intensive Care Unit (PICU) and non-PICU patients. Categorical testing utilized Chi-square and Fisher's Exact tests. Comparison between groups used T-tests or Kruskal-Wallis.
Results:
Fifteen patients (57%) required intensive care. There was no statistically significant difference in demographics between PICU and non-PICU patients, however all Black patients required intensive care. Gastrointestinal symptoms were present in 22 patients (84%). Seventeen patients (65%) had Kawasaki-like features and 12 (46%) developed coronary artery dilation. Patients requiring intensive care were less likely to have a reported history of COVID-19 disease or exposure (p = 0.0362). Statistically significant differences were also noted in peak ferritin (p = 0.0075), procalcitonin, and BNP in those who required intensive care.
Conclusions:
Although overlap exists with other hyperinflammatory conditions, our study provides further evidence that MIS-C is a distinct, albeit heterogenous, disorder with various degrees of cardiac involvement. Anakinra, in conjunction with steroid use, appears to be effective and safe in the treatment of MIS-C. This report identifies procalcitonin, peak ferritin, and BNP as potentially useful biomarkers for severity of disease.
Insights
Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare condition post-SARS-CoV-2. Anakinra and steroids show promise for treatment, with ferritin and BNP as potential severity biomarkers.
Area of Science:
- Pediatric critical care medicine
- Infectious diseases
- Rheumatology
Background:
- Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare, hyperinflammatory condition following SARS-CoV-2 infection.
- Limited research exists on MIS-C risk factors, management, and outcomes.
- This study addresses the need for further understanding of MIS-C.
Purpose of the Study:
- To describe the clinical, imaging, and laboratory characteristics of MIS-C patients.
- To detail treatments and outcomes, comparing intensive care unit (PICU) and non-PICU patients.
- To identify potential biomarkers for MIS-C severity.
Main Methods:
- Case series of 26 MIS-C patients diagnosed between April 2020 and February 2021.
- Analysis of clinical, imaging, and laboratory data.
- Statistical comparisons between PICU and non-PICU groups using Chi-square, Fisher's Exact, T-tests, and Kruskal-Wallis tests.
Main Results:
- Gastrointestinal symptoms (84%) and Kawasaki-like features (65%) were common; 46% developed coronary artery dilation.
- Fifteen patients (57%) required PICU admission; all Black patients required intensive care.
- Higher peak ferritin, procalcitonin, and BNP levels were associated with PICU admission.
Conclusions:
- MIS-C is a distinct, heterogeneous disorder with significant cardiac involvement.
- Anakinra combined with steroids appears safe and effective for MIS-C treatment.
- Procalcitonin, peak ferritin, and BNP may serve as useful biomarkers for disease severity.
More Related Videos
09:11Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
Published on: February 14, 2021
08:44Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
