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Updated: Oct 9, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Sustained reductions in unnecessary antimicrobial administration and hospital Clostridioides difficile rates via
Neil Gaffin1,2, Brad Spellberg3
1The Valley Hospital, Ridgewood, New Jersey.
Abstract:
A large community hospital sought to reduce its burden of hospital-acquired Clostridioides difficile infection (CDI). We implemented an antimicrobial stewardship program (ASP), resulting in marked reductions in unnecessary antimicrobial use, CDI rates, antimicrobial acquisition costs, with preservation of gram-negative susceptibilities. ASP programs are effective in a community setting.
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