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Updated: Oct 9, 2025

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
[Belief updating and mood congruence in depressive disorder]
H Bottemanne1, S Frileux2, A Guesdon2
1Paris Brain Institute - Institut du Cerveau (ICM), UMR 7225/UMRS 1127, CNRS / INSERM, Sorbonne university, Paris, France; Sorbonne University, Department of Philosophy, SND Research Unit, UMR 8011, CNRS, Paris, France; Department of psychiatry, Pitié-Salpêtrière hospital, DMU Neuroscience, Sorbonne university, Assistance publique-Hôpitaux de Paris (AP-HP), Paris, France.
Abstract:
Depressive disorder is characterized by a polymorphic symptomatology associating emotional, cognitive and behavioral disturbances. One of the most specific symptoms is negative beliefs, called congruent to mood. Despite the importance of these beliefs in the development, the maintenance, and the recurrence of depressive episodes, little is known about the processes underlying the generation of depressive beliefs. In this paper, we detail the link between belief updating mechanisms and the genesis of depressive beliefs. We show how depression alters information processing, generating cognitive immunization when processing positive information, affective updating bias related to the valence of belief and prediction error, and difficultie to disengage from negative information. We suggest that disruption of belief-updating mechanisms forms the basis of belief-mood congruence in depression.
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