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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

445
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
445
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

560
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
560
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

405
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
405
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

451
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
451
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

283
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
283
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

255
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
255

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Colonic tuberculosis masquerading as crohn's disease.

Harveen Kaur1, Dilbag Singh1, N C Kajal1

  • 1Department of Pulmonary Medicine, Government Medical College, Amritsar, Punjab, India.

International Journal of Mycobacteriology
|December 17, 2021
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Summary

Intestinal tuberculosis (TB) mimics Crohn's disease (CD) and colon cancer, posing diagnostic challenges. Mycobacterium tuberculosis detection in biopsies confirmed colonic TB, differentiating it from CD.

Keywords:
Colonic tuberculosisCrohn's diseasecolonoscopyhistopathological examinationmimickingultrasonography abdomen

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Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Oncology

Background:

  • Intestinal tuberculosis (TB) presents diagnostic challenges due to its similarity with other gastrointestinal conditions.
  • Crohn's disease (CD) and colon cancer share overlapping symptoms, imaging findings, and pathological features with intestinal TB.

Observation:

  • A case of colonic TB initially presented with symptoms and diagnostic workup suggestive of Crohn's disease.
  • The clinical presentation, imaging, and initial assessments were inconclusive for a definitive diagnosis.

Findings:

  • Microscopic examination of biopsy specimens revealed the presence of Mycobacterium tuberculosis.
  • Histopathological confirmation was crucial in distinguishing intestinal TB from Crohn's disease and colon cancer.

Implications:

  • Accurate diagnosis of intestinal TB is vital for appropriate treatment and patient outcomes.
  • Highlighting the importance of considering infectious etiologies, particularly TB, in the differential diagnosis of colonic diseases.
  • Emphasizes the role of microbiological confirmation in complex gastrointestinal cases.