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Epidemiology and Predictors of Hospital Outcomes of Critically Ill Pediatric Oncology Patients: A Retrospective Study

Shilpushp J Bhosale1, Malini Joshi2, Vijaya P Patil2

  • 1Division of Critical Care Medicine, Department of Anaesthesia, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

Indian Journal of Critical Care Medicine : Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine
|December 17, 2021
PubMed

Insights

Critically ill pediatric cancer patients admitted to the ICU have improving outcomes. Hematologic malignancies are associated with higher mortality, predicted by mechanical ventilation, inotropes, and coagulopathy.

Area of Science:

  • Pediatric Critical Care Medicine
  • Pediatric Oncology
  • Epidemiology of Critical Illness

Background:

  • Increasing ICU admissions for pediatric oncology patients with improving outcomes.
  • Limited data on this specific patient population necessitates further research.
  • Retrospective study to investigate epidemiology and outcome predictors.

Observation:

  • 200 pediatric oncology patients admitted to ICU over one year.
  • Exclusion of patients post-elective surgery or bone marrow transplant.
  • Data collected on demographics, diagnoses, malignancy types, and ICU interventions.

Findings:

  • Hematologic malignancies showed significantly higher hospital mortality (61.5%) compared to solid tumors (34.6%).
  • Mechanical ventilation (OR 14.64), inotropes (OR 9.81), and coagulopathy (OR 3.86) were independent predictors of hospital mortality.
  • ICU length of stay and ICU/hospital mortality were secondary outcomes analyzed.

Implications:

  • Hematologic cancer patients face higher mortality risks in the ICU.
  • Mechanical ventilation, inotropes, and coagulopathy are critical factors influencing survival.
  • Findings can inform clinical management and resource allocation for critically ill pediatric cancer patients.
Abstract

Keywords:
Critical care oncologyHematooncologyHospital mortalityICU mortalityICU outcomesIntensive care in pediatric cancerPediatric cancersSolid tumors

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