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Related Concept Videos

Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

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Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
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Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

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Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
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Respiration and Gaseous Exchange01:20

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The intricate interplay between the cardiovascular and respiratory systems is crucial for efficiently transporting respiratory gases throughout the body. Let us explore the cardiovascular system's multifaceted functions, emphasizing its pivotal role in gas exchange.
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Hemoglobin01:24

Hemoglobin

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Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
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Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

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Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
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Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Related Experiment Video

Updated: Oct 9, 2025

Author Spotlight: Utilizing Next-Generation Polymerized Human Hemoglobin for Improved Donor Lung Evaluation and Preservation in Rats
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Author Spotlight: Utilizing Next-Generation Polymerized Human Hemoglobin for Improved Donor Lung Evaluation and Preservation in Rats

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Hemoglobin-Based Oxygen Carriers: Potential Applications in Solid Organ Preservation.

Min Cao1, Guoqing Wang1, Hongli He1

  • 1Department of Critical Care Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Frontiers in Pharmacology
|December 17, 2021
PubMed
Summary

Hemoglobin-based oxygen carriers (HBOCs) can improve organ preservation by delivering oxygen, reducing injury, and enhancing graft quality. This review explores HBOCs as a promising strategy to overcome limitations in current organ preservation methods.

Keywords:
hemoglobin-based oxygen carriersischemia–reperfusion injurymachine perfusionorgan oxygenationsolid organ preservation

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Author Spotlight: Advancements and Challenges in Machine Perfusion for Liver Transplantation
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Author Spotlight: Advancements and Challenges in Machine Perfusion for Liver Transplantation

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Ex Situ Normothermic Machine Perfusion of Donor Livers
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Last Updated: Oct 9, 2025

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Author Spotlight: Advancements and Challenges in Machine Perfusion for Liver Transplantation
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Area of Science:

  • Transplantation immunology
  • Biomedical engineering
  • Organ preservation

Background:

  • Static cold storage is the standard for organ preservation but fails to address hypoxia and oxygenation.
  • Improving graft quality and expanding the donor pool remain critical challenges in transplantation.
  • Marginal donor organs and ischemia-reperfusion injury significantly impact transplant outcomes.

Purpose of the Study:

  • To review the potential applications of hemoglobin-based oxygen carriers (HBOCs) in solid organ preservation.
  • To explore HBOCs as a strategy to improve organ quality and recipient prognosis.
  • To provide insights into the mechanisms underlying HBOCs' efficacy in organ preservation.

Main Methods:

  • Literature review of studies on HBOCs in organ preservation.
  • Analysis of HBOCs' oxygen-carrying capacity and release mechanisms.
  • Evaluation of HBOCs' impact on graft injury, preservation time, and transplant outcomes.

Main Results:

  • HBOCs deliver oxygen to donor organs, meeting metabolic demands and prolonging preservation.
  • Addition of HBOCs reduces ischemia-reperfusion injury and improves graft quality.
  • HBOCs show potential to increase the number of transplantable donors and enhance recipient prognosis.

Conclusions:

  • HBOCs represent a promising advancement over traditional organ preservation solutions.
  • HBOCs can mitigate hypoxia, improve graft viability, and expand donor organ utilization.
  • Further research into HBOC mechanisms can optimize their application in solid organ transplantation.