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Clinical Usefulness of Transjugular Liver Biopsy in Patients With Hematological Diseases With Liver Dysfunction

Toru Ishikawa1, Erina Kodama2, Takamasa Kobayashi2

  • 1Department of Gastroenterology and Hepatology, Saiseikai Niigata Hospital, Niigata, JPN.

Cureus
|December 17, 2021
PubMed

Insights

Transjugular liver biopsy (TJLB) is crucial for diagnosing liver dysfunction in patients with hematological diseases when other methods fail. This study highlights TJLB

Area of Science:

  • Hepatology
  • Hematology
  • Interventional Radiology

Background:

  • Percutaneous liver biopsy is contraindicated in patients with hematological diseases and liver dysfunction.
  • Transjugular liver biopsy (TJLB) offers an alternative diagnostic method in these complex cases.
  • The clinical utility of TJLB for liver disorders in hematological patients requires further investigation.

Purpose of the Study:

  • To evaluate the clinical efficacy and diagnostic yield of Transjugular liver biopsy (TJLB).
  • To assess the role of TJLB in guiding therapeutic strategies for liver dysfunction in hematological patients.

Main Methods:

  • Retrospective analysis of 27 patients with hematological diseases and liver dysfunction requiring TJLB.
  • Review of clinical features and histological diagnoses obtained via TJLB.
  • Correlation of TJLB findings with subsequent treatment modifications.

Main Results:

  • TJLB successfully diagnosed various liver disorders, including drug-induced liver injury, nonalcoholic steatohepatitis, autoimmune hepatitis, and liver infiltration by underlying hematological diseases.
  • Specific diagnoses included drug-induced liver injury (n=8), liver infiltration (n=5), autoimmune hepatitis (n=3), nonalcoholic steatohepatitis (n=2), and others.
  • Therapeutic regimens were altered based on TJLB findings, demonstrating its clinical impact.

Conclusions:

  • Liver disorders in patients with hematological diseases have diverse etiologies.
  • Histological diagnosis via TJLB is essential for determining appropriate treatment strategies.
  • TJLB plays a vital role in managing complex liver dysfunction in hematological patients.

Keywords:
coagulation disordershematologyliver diseasepancytopeniatransjugular liver biopsy

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