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Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
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Editorial: Therapeutic Opportunities and Innovative Biomarkers in Tumor Microenvironment
Kexin Xu1, Farah Rahmatpanah2, Zhenyu Jia3
1Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.
Frontiers in Oncology
|December 17, 2021
Abstract
No abstract available in PubMed .
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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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01:27Tumor Immunotherapy
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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