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Updated: Oct 9, 2025

Transuterine Fetal Tracheal Occlusion Model in Mice
Published on: February 5, 2021
Cellular Origin(s) of Congenital Diaphragmatic Hernia
Gabriëla G Edel1,2, Gerben Schaaf3,4,5, Rene M H Wijnen1
1Department of Pediatric Surgery and Intensive Care, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands.
Abstract:
Congenital diaphragmatic hernia (CDH) is a structural birth defect characterized by a diaphragmatic defect, lung hypoplasia and structural vascular defects. In spite of recent developments, the pathogenesis of CDH is still poorly understood. CDH is a complex congenital disorder with multifactorial etiology consisting of genetic, cellular and mechanical factors. This review explores the cellular origin of CDH pathogenesis in the diaphragm and lungs and describes recent developments in basic and translational CDH research.
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