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Nuances in the Evaluation of Chest Pain in Women

Kelsey Vargas1, Anne Messman2, Phillip D Levy2,3

  • 1Department of Emergency Medicine, Cleveland Clinic Foundation/Case Western Reserve University, Cleveland, Ohio, USA.

JACC. Case Reports
|December 17, 2021
PubMed

Insights

Chest pain is a common symptom of acute coronary syndrome in both sexes. However, differences in coronary artery disease pathophysiology require specific clinical considerations for women presenting with chest pain.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Women's Health

Background:

  • Chest pain is a prevalent symptom for acute coronary syndrome (ACS) across genders.
  • Understanding sex-specific differences in ACS is crucial for effective patient management.

Observation:

  • Coronary artery disease (CAD) pathophysiology exhibits distinct characteristics between men and women.
  • These pathophysiological variations can influence clinical presentation and diagnostic approaches.

Findings:

  • The article highlights key differences in CAD pathophysiology relevant to chest pain presentation in women.
  • A case-based approach is utilized to illustrate these considerations for clinicians.

Implications:

  • Clinicians must be aware of sex-specific nuances in chest pain evaluation for ACS.
  • Tailoring diagnostic and treatment strategies based on these differences can improve outcomes for women.

Keywords:
ACS, acute coronary syndromeAMI, acute myocardial infarctionCAD, coronary artery diseaseHEART score, History, ECG, Age, Risk factors, Troponin scoreMACE, major acute coronary eventMINOCA, myocardial infarction with nonobstructive coronary arteriesPCI, percutaneous coronary interventionSCAD, spontaneous coronary artery dissectionacute coronary syndromechest painmyocardial infarctionwomen

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