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Association of androgenetic alopecia and severity of coronavirus disease 2019

Rabia Ghafoor1, Syeda Mahanum Ali1, Anant Patil2

  • 1Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.

Journal of Cosmetic Dermatology
|December 17, 2021
PubMed

Insights

Androgenetic alopecia (AGA) is more frequent and severe in men with worse COVID-19 outcomes. Severe AGA in younger men, even without comorbidities, indicates potential benefit from anti-androgen drugs for COVID-19 treatment.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Endocrinology

Background:

  • Androgenetic alopecia (AGA) is a common condition affecting both men and women.
  • The severity of coronavirus disease 2019 (COVID-19) can vary significantly among patients.
  • Understanding potential risk factors and associations for severe COVID-19 is crucial for patient management.

Purpose of the Study:

  • To investigate the association between the severity of androgenetic alopecia (AGA) and the clinical outcomes of coronavirus disease 2019 (COVID-19).
  • To compare the prevalence and severity of AGA in male and female COVID-19 patients.
  • To explore potential therapeutic implications based on observed associations.

Main Methods:

  • An observational study was conducted with 300 hospitalized COVID-19 patients.
  • Patients were assessed for the presence and severity of androgenetic alopecia using standardized scales (Hamilton-Norwood for men, Ludwig for women).
  • COVID-19 severity was categorized based on hospital outcomes, and correlations with AGA severity were analyzed.

Main Results:

  • A higher frequency and severity of AGA were observed in male COVID-19 patients (80.55% with severe AGA) compared to females (46% with AGA).
  • Males with severe AGA showed significantly worse COVID-19 outcomes (p<0.000) compared to females (p=0.273).
  • Younger male patients with severe AGA, even without comorbidities, experienced adverse COVID-19 outcomes.

Conclusions:

  • There is a significant association between the severity of androgenetic alopecia and worse hospital outcomes in men with COVID-19.
  • The findings suggest that AGA may be a risk factor for severe COVID-19, particularly in men.
  • The study supports the hypothesis that anti-androgen therapies could be a potential treatment strategy for COVID-19 patients, especially those with severe AGA.
Abstract

Keywords:
androgenetic alopeciacoronavirus disease-19female pattern baldnesshns ludwig scalemale pattern baldness

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