Related Experiment Video

Updated: Oct 9, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

566

Identifying the hub genes and immune infiltration related to pyroptosis in rheumatoid arthritis

Wei Xie1, Zhengyuan Wu2

  • 1Department of Orthopedics, Minzu Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

Medicine
|December 17, 2021
PubMed

Insights

This study identifies key pyroptosis biomarkers, EGFR and JUN, in rheumatoid arthritis (RA). These findings offer new insights into RA

Area of Science:

  • Immunology
  • Genetics
  • Molecular Biology

Background:

  • Rheumatoid arthritis (RA) is a prevalent autoimmune joint disorder with incompletely understood mechanisms.
  • Pyroptosis, a form of programmed cell death, is linked to RA pathogenesis.
  • Validated biomarkers for targeting pyroptosis in RA therapy are lacking.

Purpose of the Study:

  • To identify crucial pyroptosis biomarkers in rheumatoid arthritis (RA).
  • To investigate the relationship between pyroptosis and immune cell infiltration in RA.
  • To explore potential therapeutic targets for RA based on pyroptosis pathways.

Main Methods:

  • Utilized Gene Expression Omnibus (GEO) database for synovial tissue gene expression profiles.
  • Identified differentially expressed pyroptosis genes (DEPGs) in RA.
  • Employed the CIBERSORT algorithm to analyze immune infiltration patterns.
  • Performed Gene Ontology and pathway enrichment analyses for identified hub genes.

Main Results:

  • Identified EGFR and JUN as two hub differentially expressed pyroptosis genes (DEPGs) in RA.
  • EGFR and JUN are implicated in signaling pathways including ErbB, PD-1 checkpoint, and GnRH.
  • Found significant correlations between pyroptosis genes (EGFR, JUN) and specific immune cell types.

Conclusions:

  • This study introduces a novel approach to pinpointing hub DEPGs in RA.
  • Identified EGFR and JUN as critical genes linking pyroptosis and immune infiltration in RA.
  • Findings may offer new diagnostic and therapeutic strategies for rheumatoid arthritis patients.

More Related Videos

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

446
Detecting Migration and Infiltration of Neutrophils in Mice10:33

Detecting Migration and Infiltration of Neutrophils in Mice

Published on: February 6, 2020

12.2K

Related Concept Videos

The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
9.5K
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.5K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.7K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.9K