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Link between childhood tobacco exposure and childhood psoriasis: A case-control study

Mehmet Fatih Atak1, Nihal Kundakci1, Banu Farabi2

  • 1Dermatology Department, Ankara University, Ankara, Turkey.

Pediatric Dermatology
|December 17, 2021
PubMed

Insights

Environmental tobacco smoke exposure at home is a significant risk factor for childhood psoriasis (CP). This preventable exposure increases the likelihood of developing CP in children.

Area of Science:

  • Dermatology
  • Pediatrics
  • Environmental Health

Background:

  • Childhood psoriasis (CP) affects approximately 128 per 100,000 children.
  • Limited data exist on the impact of intrauterine and environmental tobacco smoke exposure on childhood psoriasis development.
  • This study investigates these risk factors in the Turkish pediatric population.

Purpose of the Study:

  • To examine the association between intrauterine and environmental tobacco smoke exposure and childhood psoriasis.
  • To identify preventable risk factors for childhood psoriasis in a Turkish cohort.

Main Methods:

  • A case-control study involving 130 children with psoriasis and 390 controls.
  • Univariate and multivariate conditional logistic regression analyses were employed.
  • Odds ratios (OR) and 95% confidence intervals (CI) were calculated to estimate relative risks.

Main Results:

  • Environmental tobacco smoke exposure was significantly associated with childhood psoriasis (OR: 2.23, 95% CI: 1.39-3.58).
  • No significant relationship was found between intrauterine tobacco exposure and childhood psoriasis (OR: 1.61, 95% CI: 0.75-3.43).
  • The association with environmental tobacco smoke remained significant after adjusting for family history of psoriasis and obesity.

Conclusions:

  • Environmental tobacco smoke exposure in the home is an important, preventable risk factor for childhood psoriasis.
  • Further large-scale cohort studies are recommended to confirm the relationship between environmental tobacco smoke and childhood psoriasis.
Abstract

Keywords:
childhood psoriasisintrauterine exposurenicotinepassivesmoking

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