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Motor development of children after a human Parechovirus or Enterovirus infection: 24 months follow-up

Stephanie C de Crom1, M Ted van Hinsbergh2, Inge A van Beijsterveldt3

  • 1Department of Pediatrics, Bravis Hospital, Roosendaal, the Netherlands - stephanie_de_crom@hotmail.com.

Minerva Pediatrics
|December 17, 2021
PubMed

Insights

Human Parechovirus (HPeV) and Enterovirus (EV) infections in children did not significantly impact motor development 24 months later. This study focused on Caucasian children, unlike previous research on Asian populations.

Area of Science:

  • Pediatric Neurology
  • Developmental Pediatrics
  • Infectious Diseases

Background:

  • Human Parechovirus (HPeV) and Enterovirus (EV) are common childhood viral infections, often causing meningitis.
  • Limited data exists on the long-term motor development of Caucasian children following HPeV or EV infections.
  • Previous studies primarily focused on Enterovirus 71 in Asian children, a different epidemiological context.

Purpose of the Study:

  • To investigate the impact of HPeV and EV infections on the motor development of young Caucasian children.
  • To compare motor outcomes between infected children and their uninfected peers.
  • To assess fine and gross motor function 24 months post-infection.

Main Methods:

  • Prospective, multicenter, blinded cohort study.
  • Involved 157 children, including those with HPeV/EV infections (meningitis or elsewhere) and uninfected controls.
  • Utilized Bayley Scales of Infant Development-3 (BSID-3) and Movement Assessment Battery for Children-2 (M-ABC-2-NL) at 24 months follow-up.

Main Results:

  • 10% showed impaired total motor outcome, 27% impaired gross motor function, and 6% impaired fine motor function.
  • No significant differences in motor development were observed between infected children (meningitis or elsewhere) and uninfected peers.
  • Subgroup analysis, controlling for age and gender, also revealed no significant differences.

Conclusions:

  • HPeV and EV infections in Dutch children do not lead to significant differences in motor development at 24 months follow-up.
  • Findings suggest these common viral infections have a negligible long-term impact on motor skills in this population.
  • Contributes to understanding the neurodevelopmental sequelae of common viral infections in Western children.
Abstract

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