The association of angiotensin-converting enzyme gene insertion/deletion polymorphism with bronchial asthma

Bronchial asthma (BA) is among the most prevalent chronic inflammatory disorders of the lung airways, and it has become clear that a mixture of genetic predisposition and environmental factors plays a critical role in its pathogenesis. The aim of presented review is to analyze the published data on the possible role of ACE gene polymorphism in BA development. The article is based on available literature found in Pubmed, Elsevier, Scopus, and Google scholar databases. We have found that ACE I/D polymorphism may contribute to an important molecular mechanisms of BA development (specially D/D genotype), and may become a useful tool in risk assessment and in designing effective treatment approaches. The difference in the literature on the role of ACE alleles and genotypes can be explained by minor influence of the investigated genetic component and contributions of other genetic variations, as well as other environmental factors, considering multifactorial causes of BA.