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Peptide-based Identification of Functional Motifs and their Binding Partners
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Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

Clinical, immunologic, and serologic findings in men at risk for acquired immunodeficiency syndrome. The San

W Lang, R E Anderson, H Perkins

    JAMA
    |January 16, 1987
    PubMed

    Insights

    Nearly half of homosexual/bisexual men studied had human immunodeficiency virus (HIV) antibodies. Clinical signs, excluding lymphadenopathy, correlated with immune impairment in HIV-positive individuals.

    Area of Science:

    • Epidemiology
    • Immunology
    • Public Health

    Background:

    • The human immunodeficiency virus (HIV) epidemic disproportionately affected men who have sex with men.
    • Understanding the prevalence and clinical indicators of HIV infection in specific populations is crucial for public health interventions.

    Purpose of the Study:

    • To determine the prevalence of HIV infection among homosexual and bisexual men in San Francisco.
    • To identify clinical signs and laboratory markers associated with HIV infection and immune impairment.

    Main Methods:

    • A population-based probability sample of 1034 single men in San Francisco was recruited.
    • Participants underwent serological testing for HIV antibodies.
    • Clinical examinations and laboratory tests, including T cell subset analysis and skin test reactivity, were performed.

    Main Results:

    • Forty-nine percent of homosexual/bisexual men tested positive for HIV antibodies; all heterosexual men were negative.
    • Among seropositive men, 29% had marked lymphadenopathy, and 16% presented with at least two other HIV-suggestive symptoms.
    • Presence of multiple clinical signs (excluding lymphadenopathy) correlated with HIV infection, reduced skin test reactivity, and lower Leu 3a T helper cell counts.

    Conclusions:

    • HIV infection was highly prevalent in this San Francisco cohort of homosexual/bisexual men.
    • Clinical manifestations, in conjunction with immunological markers like T cell counts, are important indicators of HIV infection and immune status.
    • Lymphadenopathy alone was not a reliable indicator of the severity of immune impairment.

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