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Generalized pain hypersensitivity and associated factors in gout
Peter M Ten Klooster1, Jannis T Kraiss1, Rik Munters2
1Department of Psychology, Health and Technology, University of Twente.
Rheumatology (Oxford, England)
|December 17, 2021
Summary
Generalized pain hypersensitivity is common in gout patients, affecting over 20%. Factors like younger age and fibromyalgia are associated with this non-inflammatory pain, impacting gout management.
Area of Science:
- Rheumatology
- Pain Medicine
- Clinical Research
Background:
- Central pain sensitization is prevalent in inflammatory arthritis.
- Its presence in gout patients remains under-investigated.
- Gout's intermittent nature may influence pain presentation.
Purpose of the Study:
- To investigate generalized pain hypersensitivity in gout patients.
- To identify factors associated with this pain phenotype.
- To inform improved pain management strategies for gout.
Main Methods:
- Cross-sectional survey of crystal-proven gout outpatients.
- Utilized the generalized pain questionnaire (GPQ) for screening.
- Employed logistic regression and LASSO analysis for associations.
Main Results:
- 20.6% of gout patients screened positive for generalized pain hypersensitivity.
- Lower age, fibromyalgia, and social role difficulties were associated.
- Urate-lowering therapy use was lower in those with hypersensitivity.
Conclusions:
- Generalized pain hypersensitivity is common in gout.
- Screening for non-inflammatory pain is crucial for effective gout pain management.
- This finding has implications for treatment approaches beyond urate lowering.
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