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Diversity in modern heart failure trials: Where are we, and where are we going

Uzoma Anaba1, Abiodun Ishola2, Alisha Alabre1

  • 1Division of Cardiology, Ohio State University Medical Center, Columbus, OH, USA.

International Journal of Cardiology
|December 17, 2021
PubMed

Insights

Clinical trials for cardiovascular disease (CVD) must improve Black patient representation. Addressing inequities in heart failure trials is crucial for advancing equitable cardiovascular care for all populations.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Trial Diversity
  • Health Equity

Background:

  • Historically underrepresented groups face inequities in clinical trials.
  • The COVID-19 pandemic highlighted existing disparities in healthcare access and research.
  • Cardiovascular disease (CVD) research has historically lacked diverse participant representation.

Purpose of the Study:

  • To examine the representation of Black individuals in landmark heart failure clinical trials.
  • To discuss existing inequities in cardiovascular research.
  • To propose solutions for improving diversity in cardiovascular clinical trials.

Main Methods:

  • Review of recent pivotal cardiovascular disease (CVD) trials.
  • Specific focus on heart failure (HF) trials impacting contemporary treatment strategies.
  • Analysis of participant demographics with an emphasis on Black representation.

Main Results:

  • Historic inequities persist in cardiovascular clinical trials, including those for heart failure.
  • Underrepresentation of Black patients in foundational trials impacts current treatment guidelines and drug approvals.
  • Lack of diversity limits the generalizability of findings and perpetuates health disparities.

Conclusions:

  • Intentional efforts are needed to increase diversity in cardiovascular clinical trials.
  • Building a diverse clinical trial workforce is essential for advancing health equity.
  • Addressing representation gaps in heart failure research is critical for equitable cardiovascular care.

Keywords:
BlackCardiovascular clinical trialsDisparities

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