Related Experiment Video
Updated: Oct 9, 2025

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Outcomes after reperfusion therapies in patients with ACA stroke: A multicenter cohort study from the EVATRISP
A Filioglo1, N Simaan1, A Honig1
1Departments of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Insights
For anterior cerebral artery strokes, endovascular thrombectomy (EVT) and intravenous thrombolysis (IVT) show similar safety and effectiveness. Treatment outcomes were not affected by clot location within the anterior cerebral artery (ACA).
Area of Science:
- Neurology
- Vascular Neurology
- Interventional Neurology
Background:
- Anterior cerebral artery (ACA) strokes often lead to poor patient outcomes.
- The optimal acute treatment for ACA occlusive strokes remains uncertain.
Purpose of the Study:
- To compare the effectiveness and safety of endovascular thrombectomy (EVT) versus intravenous thrombolysis (IVT) for acute anterior cerebral artery (ACA) strokes.
Main Methods:
- Retrospective analysis of 92 patients with isolated ACA stroke from the EVATRISP registry.
- Comparison of outcomes between patients treated with EVT and those treated with IVT using multivariate regression analysis.
Main Results:
- No significant differences in favorable outcome, mortality, or symptomatic intracranial hemorrhage between EVT and IVT groups.
- EVT patients more frequently presented with wake-up strokes and proximal occlusions.
- Clot location within the ACA (A1 vs. A2/A3 segments) did not influence treatment outcomes.
Conclusions:
- Both IVT and EVT appear to be safe and similarly effective treatments for ACA strokes.
- Treatment efficacy for ACA strokes may be independent of the specific clot location within the artery.
Background:
Patients with stroke secondary to occlusions of the anterior cerebral artery (ACA) often have poor outcomes. The optimal acute therapeutic intervention for these patients remains unknown.
Methods:
Patients with isolated ACA-stroke were identified from 10 centers participating in the EndoVascular treatment And ThRombolysis in Ischemic Stroke Patients (EVATRISP) prospective registry. Patients treated with endovascular thrombectomy (EVT) were compared to those treated with intravenous thrombolysis (IVT). Odds ratios with 95% confidence intervals (OR; 95%CI) were calculated using multivariate regression analysis.
Results:
Included were 92 patients with ACA-stroke. Of the 92 ACA patients, 55 (60%) were treated with IVT only and 37 (40%) with EVT (±bridging IVT). ACA patients treated with EVT had more often wake-up stroke (24% vs. 6%, p = 0.044) and proximal ACA occlusions (43% vs. 24%, p = 0.047) and tended to have higher stroke severity on admission [NIHSS: 10.0 vs 7.0, p = 0.054). However, odds for favorable outcome, mortality or symptomatic intracranial hemorrhage did not differ significantly between both groups. Exploration of the effect of clot location inside the ACA showed that in patients with A1 or A2/A3 ACA occlusions the chances of favorable outcome were not influenced by treatment allocation to IVT or EVT.
Discussion:
Treatment with either IVT or EVT could be safe with similar effect in patients with ACA-strokes and these effects may be independent of clot location within the occluded ACA.
Related Concept Videos
Acute Coronary Syndrome III: Diagnostic Studies
Acute Coronary Syndrome IV: Interprofessional Care
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Acute Coronary Syndrome I: Introduction
Atherosclerosis III: Management

