Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Nomenclature01:17

Drug Nomenclature

2.4K
During the development of a new pharmaceutical, the manufacturer initially assigns a code name to the drug. Once approved, the drug receives a United States Adopted Name (USAN)—a generic, nonproprietary designation. Upon being listed in the United States Pharmacopeia, this nonproprietary name becomes the drug's official name. Additionally, the manufacturer assigns a proprietary name or trademark, which serves as the brand name under which the drug is marketed. It is worth noting that...
2.4K
Pharmacokinetic Models: Overview01:20

Pharmacokinetic Models: Overview

1.3K
Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
1.3K
Improving Translational Accuracy02:07

Improving Translational Accuracy

12.0K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
12.0K
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

143
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
143
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

890
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
890
Drug Discovery: Overview01:26

Drug Discovery: Overview

9.4K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
9.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-Omics Reveals the Impact of Domestic Wastewater Input on the Dissolved Organic Carbon Pool and Microbial Community in the Qiantang River Estuary.

Microorganisms·2026
Same author

Unraveling coronavirus cell invasion: The role of glycan receptors in human coronavirus-HKU1 cell entry.

Infectious diseases & immunity·2026
Same author

MRI-guided risk stratification for neoadjuvant immunotherapy in rectal cancer.

Frontiers in immunology·2026
Same author

Author Correction: A broadly protective antibody targeting gammaherpesvirus gB.

Nature·2026
Same author

Advances in BODIPY Derivatives for Antibacterial Phototherapy.

Angewandte Chemie (International ed. in English)·2026
Same author

A pH-responsive composite hydrogel based on konjac glucomannan and its oxidized derivatives: synthesis, characterization and swelling behavior.

Current research in food science·2026
Same journal

OpenIMC: an open-source platform for analyzing single-cell and spatial proteomics by imaging mass cytometry.

BMC bioinformatics·2026
Same journal

NAP: an open source pipeline for cross-domain microbiome profiling using Nanopore sequencing-derived amplicon data.

BMC bioinformatics·2026
Same journal

SurvGME: an R package for survival analysis with graphical and measurement error models.

BMC bioinformatics·2026
Same journal

SimMapNet: a Bayesian framework for gene regulatory network inference using gene ontology similarities as external hint.

BMC bioinformatics·2026
Same journal

Dual channel drug-drug interactions extraction based on cross attention.

BMC bioinformatics·2026
Same journal

FeSseqdb: a curated sequence-level database and interpretable machine learning framework for identifying iron-sulfur proteins.

BMC bioinformatics·2026
See all related articles

Related Experiment Video

Updated: Oct 9, 2025

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness
03:14

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness

Published on: December 6, 2024

723

Deep learning with language models improves named entity recognition for PharmaCoNER.

Cong Sun1, Zhihao Yang2, Lei Wang3

  • 1School of Computer Science and Technology, Dalian University of Technology, Dalian, China.

BMC Bioinformatics
|December 18, 2021
PubMed
Summary
This summary is machine-generated.

Leveraging deep learning language models, this study enhances pharmacological named entity recognition (NER) for Spanish biomedical texts. BERT models achieved state-of-the-art results on the PharmaCoNER dataset, demonstrating the effectiveness of these approaches.

Keywords:
BERTLanguage modelNERNamed entity recognitionText mining

More Related Videos

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

685
Cloud-Based Phrase Mining and Analysis of User-Defined Phrase-Category Association in Biomedical Publications
09:20

Cloud-Based Phrase Mining and Analysis of User-Defined Phrase-Category Association in Biomedical Publications

Published on: February 23, 2019

8.9K

Related Experiment Videos

Last Updated: Oct 9, 2025

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness
03:14

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness

Published on: December 6, 2024

723
Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

685
Cloud-Based Phrase Mining and Analysis of User-Defined Phrase-Category Association in Biomedical Publications
09:20

Cloud-Based Phrase Mining and Analysis of User-Defined Phrase-Category Association in Biomedical Publications

Published on: February 23, 2019

8.9K

Area of Science:

  • Biomedical Natural Language Processing
  • Computational Linguistics
  • Pharmacology

Background:

  • Accurate recognition of pharmacological entities is crucial for drug discovery and biomedical knowledge extraction.
  • Existing efforts primarily focus on English, leaving a gap in multilingual biomedical NER.
  • The PharmaCoNER challenge addresses pharmacological entity recognition in Spanish biomedical texts.

Purpose of the Study:

  • To explore and compare various BERT models for the PharmaCoNER task.
  • To investigate the effectiveness of deep learning language models for Spanish biomedical NER.
  • To leverage existing NLP resources for the PharmaCoNER challenge.

Main Methods:

  • Utilized and compared representative BERT models.
  • Applied deep learning with language models to the PharmaCoNER dataset.
  • Investigated the impact of domain knowledge, WordPiece tokenization, and character case.

Main Results:

  • Deep learning language models significantly improved performance on the PharmaCoNER dataset.
  • Achieved state-of-the-art performance with a maximum F1-score of 92.01%.
  • Demonstrated the effectiveness of BERT models for Spanish pharmacological NER.

Conclusions:

  • Biomedical domain knowledge is more impactful than native language for BERT models on PharmaCoNER.
  • WordPiece tokenization helps mitigate out-of-vocabulary limitations.
  • Custom domain-specific vocabularies and character case considerations can further enhance model performance.