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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cytotoxic T Cells-mediated Immune Response01:27

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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Related Experiment Video

Updated: Oct 9, 2025

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
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[T cell-based immunotherapies in solid tumors].

Estelle Baulu1, Aurore Dougé2, Nicolas Chuvin3

  • 1Centre de recherche en cancérologie de Lyon, 28, rue Laennec, 69008 Lyon, France; ErVaccine Technologies, 28, rue Laennec, 69008 Lyon, France.

Bulletin Du Cancer
|December 18, 2021
PubMed
Summary

Adoptive T cell therapies, including tumor-infiltrating lymphocytes (TILs), chimeric antigen receptor (CAR), and T cell receptor (TCR) engineered T cells, show promise for solid tumors. Challenges like target selection and the tumor microenvironment require further research for effective treatment.

Keywords:
CAR TCAR-TCell therapySolid tumorsTCR-TTILTILsThérapie cellulaireTumeurs solides

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Area of Science:

  • Immunology
  • Oncology
  • Biotechnology

Background:

  • Adoptive T cell therapy is a promising approach for treating solid tumors.
  • Current strategies include tumor-infiltrating lymphocytes (TILs), chimeric antigen receptor (CAR) T cells, and T cell receptor (TCR) T cells.

Purpose of the Study:

  • To review the pros and cons of different adoptive T cell therapy approaches for solid tumors.
  • To discuss challenges and future perspectives in the field.

Main Methods:

  • Review of existing literature on adoptive T cell therapies.
  • Comparative analysis of TILs, CAR T cells, and TCR T cells.

Main Results:

  • Each therapy has unique advantages and disadvantages.
  • Obstacles include optimal target selection and overcoming the tumor microenvironment.

Conclusions:

  • Adoptive T cell therapies offer new perspectives for solid tumor treatment.
  • Further research is needed to optimize target selection and address tumor microenvironment challenges.