[Positron emission tomography/computed tomography (PET/CT) in multiple myeloma]
Christos Sachpekidis1, Hartmut Goldschmidt2,3, Antonia Dimitrakopoulou-Strauss4
1Klinische Kooperationseinheit Nuklearmedizin, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69210, Heidelberg, Deutschland. c.sachpekidis@dkfz-heidelberg.de.
Positron emission tomography/computed tomography (PET/CT) is a powerful tool for multiple myeloma (MM) management, aiding diagnosis, prognosis, and treatment response evaluation. Its role in assessing minimal residual disease (MRD) is significant, with increasing future applications.
Area of Science:
- Nuclear Medicine
- Oncology
- Radiology
Background:
- Imaging is crucial for multiple myeloma (MM) management.
- Morphological imaging includes X-ray, CT, and MRI.
- Hybrid positron emission tomography/CT (PET/CT) with 18F-fluorodeoxyglucose (18F-FDG) is increasingly utilized.
Purpose of the Study:
- To review major applications of PET/CT in MM diagnosis and management.
- To provide guidance on PET/CT interpretation for MM.
Main Methods:
- Review of background knowledge and guideline recommendations for MM imaging.
- Inclusion of recent study findings on PET/CT in MM.
Main Results:
- 18F-FDG PET/CT excels in detecting medullary and extramedullary MM disease.
- PET/CT is a reliable predictor of survival and the most robust method for evaluating treatment response.
- PET/CT plays a significant role in minimal residual disease (MRD) assessment, though interpretation can be challenging due to false results and disease heterogeneity.
Conclusions:
- PET/CT holds high value in MM diagnosis, prognosis, and treatment response assessment.
- The utilization of PET/CT in MM management is projected to grow.
- Despite challenges like availability and interpretation, PET/CT is a key imaging modality for MM.
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