Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Central Systolic Blood Pressure and Left Ventricular Mass: Findings From the International 24-Hour Aortic Blood Pressure Consortium.

Journal of the American Heart Association·2026

Same author

Apical hypercontractility mitigates impaired diastolic filling and lower intraventricular haemodynamic forces in human bed rest.

Experimental physiology·2026

Same author

Radon balneotherapy in rheumatologic diseases: potential mechanisms and implications for cardiovascular autonomic control and inflammation.

Clinical rheumatology·2026

Same author

Monte Carlo-Based Prediction of Residual Dipolar Couplings in Weakly Aligned Molecules.

Journal of chemical theory and computation·2026

Same author

Novel hypertension phenotypes based on cross-classification of 24-h brachial and aortic SBP.

Journal of hypertension·2026

Same author

Tonometer- and ultrasound-based pulse wave analysis - a comparative study.

Computer methods and programs in biomedicine·2026

Same journal

Long-term adverse cardiovascular changes induced by cocoa shell extract administration through lactation in fetal undernourished and control rats.

Experimental physiology·2026

Same journal

Divergent skeletal muscle metabolite exchange in insulin-like growth factor-1-stimulated myotubes and resistance-exercised human muscle.

Experimental physiology·2026

Same journal

Galectin-3 plasma levels are associated with left atrial contractile function in long-distance runners.

Experimental physiology·2026

Same journal

Thermal and cardiovascular responses to sauna are attenuated by adding cold water immersion to cooling breaks.

Experimental physiology·2026

Same journal

Impairments in mitochondrial dynamics and morphology in skeletal muscle of breast cancer patients after a single paclitaxel administration.

Experimental physiology·2026

Same journal

How physiology solves the gene-centric impasse.

Experimental physiology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Oct 9, 2025

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs

Published on: July 12, 2022

A comparison between left ventricular ejection time measurement methods during physiological changes induced by

Stefan Orter^1,2, Stefan Möstl³, Martin Bachler¹

¹Center for Health & Bioresources, AIT Austrian Institute of Technology, Vienna, Austria.

Experimental Physiology

|December 18, 2021

Summary

This summary is machine-generated.

Easy-to-use oscillometric left ventricular ejection time (LVET) measurements closely matched echocardiographic LVET, proving useful for monitoring cardiovascular changes during spaceflight and in clinical settings for patients with altered ejection times.

Keywords:

head-down tilt bed rest left ventricular ejection time oscillometry systolic time intervals validation

More Related Videos

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse

Published on: April 27, 2019

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Published on: November 28, 2018

Related Experiment Videos

Last Updated: Oct 9, 2025

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs

Published on: July 12, 2022

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse

Published on: April 27, 2019

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Published on: November 28, 2018

Area of Science:

Cardiovascular Physiology
Space Medicine
Clinical Diagnostics

Background:

Systolic time intervals (STIs) may serve as indicators of cardiovascular deconditioning.
Assessing cardiovascular responses during prolonged head-down tilt (HDT) is crucial for spaceflight and clinical monitoring.

Purpose of the Study:

To validate oscillometric LVET (LVET_osci) against echocardiographic LVET (LVET_echo).
To investigate the progression of LVET index (LVETI), pre-ejection period index (PEPI), total electromechanical systole index (QS2I), and PEP/LVET ratio during 60 days of HDT.
To evaluate the potential of LVET_osci for monitoring cardiovascular adaptation and deconditioning.

Main Methods:

Simultaneous measurement of LVET using oscillometry and echocardiography.
Assessment of STIs (LVETI, PEPI, QS2I, PEP/LVET) during 60 days of strict HDT bed rest in 24 subjects.
Correlation and concordance analysis between oscillometric and echocardiographic measurements.

Main Results:

LVET_osci and LVET_echo demonstrated good agreement in effect direction, with significant correlation (r=0.73, P<0.05) by the end of bed rest.
A high concordance rate (0.96) was observed for the shortening of LVET during HDT between both methods.
Significant changes in STIs were observed during HDT: decreased LVETI and QS2I, prolonged PEPI and PEP/LVET ratio. LVETI recovered to baseline within 4 days post-bed rest.

Conclusions:

Oscillometric LVET is a valid and easy-to-use method comparable to echocardiography for assessing cardiovascular changes.
LVET_osci can effectively monitor cardiovascular deconditioning during prolonged HDT, relevant for spaceflight and clinical applications.
The study highlights the utility of STIs for tracking cardiovascular adaptation and potential deconditioning in simulated microgravity and clinical scenarios.