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Feasibility and effectiveness of prone position ventilation technique for postoperative acute lung injury in infants
Yu-Lu Xu1, Ya-Ping Mi1, Meng-Xin Zhu1
1Children's Hospital of Fudan University, 399 Wanyuan Road, Minhang District, Shanghai, China.
Insights
This study assesses prone position ventilation for infants with acute lung injury after congenital heart surgery. Findings may guide improved airway management strategies in pediatric cardiac intensive care.
Area of Science:
- Pediatric critical care medicine
- Respiratory physiology
- Surgical outcomes
Background:
- Prone position ventilation is a lung protection strategy, more feasible in children than adults.
- Pediatric acute respiratory distress syndrome research has focused on prone ventilation's oxygenation benefits.
- Limited high-quality studies explore prone ventilation's effects post-pediatric cardiac surgery.
Purpose of the Study:
- To evaluate the feasibility and effectiveness of prone position ventilation.
- To assess outcomes in infants with postoperative acute lung injury after congenital heart disease surgery.
Main Methods:
- Single-center randomized controlled trial.
- 68 pediatric patients with acute lung injury post-congenital heart surgery.
- Comparison between prone position ventilation and usual care (control).
Main Results:
- Primary outcomes: lung compliance and oxygenation index.
- Secondary outcomes: mechanical ventilation duration, intensive care unit stay, reintubation, and complication rates.
Conclusions:
- Investigating prone position ventilation feasibility and effectiveness in pediatric cardiac surgery patients.
- Results may inform strategies for improved airway management post-congenital heart surgery.
Background:
Prone position ventilation is a widely used lung protection ventilation strategy. The strategy is more convenient to implement in children compared to adults. Due to the precise mechanism of improving oxygenation function, development of pediatric prone ventilation technology has been largely focused on children with acute respiratory distress syndrome. There is a paucity of high-quality studies investigating the effects of prone position ventilation after pediatric cardiac surgery. The purpose of this study is to evaluate the feasibility and effectiveness of prone position ventilation in infants who develop postoperative acute lung injury after surgery for congenital heart disease.
Methods:
A single-center, randomized controlled trial of pediatric patients with acute lung injury after surgery for congenital heart disease who will receive prone position ventilation or usual care (control group). A total of 68 children will be enrolled according to the inclusion criteria. The main outcome measures will be lung compliance and oxygenation index. The secondary outcomes will be duration of mechanical ventilation, length of stay in cardiac intensive care unit, reintubation rate, and complication rate.
Discussion:
This study will investigate the feasibility and effectiveness of prone position ventilation techniques in children who develop postoperative acute lung injury after surgery for congenital heart disease. The results may help inform strategies to improve airway management after surgery for congenital heart disease.
Trial Registration:
ClinicalTrials.gov NCT04607993 . Initially registered on 29 October 2020.
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