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    Probiotics show promise in preventing and treating oral mucositis caused by cancer therapy. This systematic review and meta-analysis suggests potential benefits for patients undergoing cancer treatment.

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    Area of Science:

    • Oncology
    • Microbiology
    • Gastroenterology

    Background:

    • Cancer therapy, including chemotherapy and radiotherapy, frequently causes oral mucositis, a painful side effect.
    • Oral mucositis significantly impacts patients' quality of life and can lead to treatment interruptions.
    • Current management strategies for oral mucositis have limitations.

    Purpose of the Study:

    • To systematically review and meta-analyze the existing evidence on the effectiveness of probiotics in preventing and treating cancer therapy-induced oral mucositis.
    • To evaluate the potential role of probiotics as an adjunct therapy in oncology care.

    Main Methods:

    • A systematic literature search was conducted across major databases.
    • Studies involving probiotics for the prevention or treatment of oral mucositis in cancer patients were included.
    • Data were extracted and analyzed using meta-analysis techniques.

    Main Results:

    • The meta-analysis indicated that probiotics may reduce the incidence and severity of oral mucositis in patients undergoing cancer therapy.
    • Specific probiotic strains and dosages showed varying degrees of efficacy.
    • Further research is needed to establish optimal protocols.

    Conclusions:

    • Probiotics represent a potential therapeutic strategy for managing cancer therapy-induced oral mucositis.
    • The findings support further investigation into the clinical application of probiotics in supportive cancer care.
    • Personalized probiotic interventions may be beneficial for cancer patients.