TRANSCORNEAL ELECTRICAL STIMULATION THERAPY MAY HAVE A STABILIZATION EFFECT ON MULTIFOCAL ELECTRORETINOGRAPHY FOR...

To assess the effects of transcorneal electrical stimulation (TES) on several measures of visual function in retinitis pigmentosa.

This prospective, randomized, fellow-eye-controlled study includes 30 eyes of 15 patients with retinitis pigmentosa. Each patient's eyes were randomly selected as treatment (TE) and control eye (CE), and 30 minutes/week TES was applied for 6 months. Patient evaluations were performed before and after TES, including comprehensive ophthalmological examination, visual fields, full-field and multifocal electroretinography, microperimetry, and optical coherence tomography. All parameters were compared before and after TES and between TE and CE.

After TES, the mean signal amplitudes in multifocal electroretinography were stabilized in TE. The mean signal amplitudes in CE decreased in every ring, reaching significance in the fifth ring (847.15 ± 393.94 and 678.77 ± 282.66 nV, P = 0.039, before and after TES, respectively). The changes in the mean signal amplitudes of TE and CE were -0.38 ± 295.53 and -185.15 ± 332,62 nV in second (P = 0.046), 36.69 ± 326.4 and -143.38 ± 317,41 nV in fourth (P = 0.028), and -17.46 ± 333.07 and -168.38 ± 297,14 nV in fifth rings (P = 0.046), respectively. The decrease in the mean signal amplitudes between 2° and 20° midperipheral retina was significantly less in TE (-33.59 ± 225,1 nV) than CE (-205.56 ± 345.1 nV) (P = 0.011). There were no significant changes in other parameters.

The progression in multifocal electroretinography might be stabilized with TES. Further studies with larger sample sizes and a longer follow-up are needed to conclude that TES reduces retinitis pigmentosa progression.