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Urinary excretion of epidermal growth factor in the newborn

N J Evans, N Rutter, H Gregory

    Early Human Development
    |December 1, 1986
    PubMed

    Insights

    Newborns excrete epidermal growth factor (EGF) from birth. Urinary EGF levels are higher in term infants and rise with age, with preterm infants showing a delayed increase.

    Area of Science:

    • Neonatal physiology
    • Biomarkers in pediatrics

    Background:

    • Urinary epidermal growth factor (EGF) is a key protein.
    • Understanding EGF excretion patterns in newborns is crucial for assessing development.

    Purpose of the Study:

    • To investigate serial urinary EGF excretion in newborns.
    • To correlate EGF levels with gestational age and postnatal development.

    Main Methods:

    • Serial urinary EGF measurements were performed on 36 infants.
    • Infants ranged from 26 to 40 weeks gestation, studied from birth to 3 months.

    Main Results:

    • All infants excreted EGF from birth.
    • Term infants showed higher initial excretion than preterm infants.
    • Urinary EGF excretion correlated with conceptional age, not birth status, and showed a delayed rise in preterm infants.

    Conclusions:

    • Urinary EGF excretion is a reliable indicator of conceptional age in newborns.
    • EGF levels do not correlate with rapid lung and skin maturation in preterm infants.

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