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Multiorgan microphysiological systems as tools to interrogate interorgan crosstalk and complex diseases
1Department of Medicine, Johns Hopkins University School of Medicine, Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA.
FEBS Letters
|December 19, 2021
Summary
Microphysiological systems (MPSs) offer new ways to study complex metabolic and inflammatory diseases by mimicking human physiology. These systems can reveal hidden links between organ communication, metabolism, and immunity.
Area of Science:
- Biomedical Engineering
- Systems Biology
- Physiology
Background:
- Metabolic and inflammatory disorders are rising globally.
- These complex diseases are systemic, often lack clear origins, and have no cures.
- Understanding causal factors in disease progression is challenging due to complexity.
Purpose of the Study:
- To discuss the current state of modeling multiorgan physiology.
- To evaluate opportunities and challenges in using microphysiological systems (MPSs).
- To explore how MPSs can clarify systemic metabolic and inflammatory diseases.
Main Methods:
- Utilizing microphysiological systems (MPSs) to mimic human physiology.
- Connecting multiple MPSs to scale biological complexity.
- Implementing continuous multiomic monitoring.
Main Results:
- MPSs offer a novel approach to model complex physiological interactions.
- Controlled MPS networks can reveal interorgan crosstalk.
- Multiomic data can identify links between metabolism and immunity.
Conclusions:
- MPSs hold promise for unraveling the complexities of systemic diseases.
- This technology may identify new therapeutic targets for metabolic and inflammatory conditions.
- Further development is needed to fully leverage MPS capabilities.
