Related Experiment Video
Updated: Oct 9, 2025
Hippocampal Neuronal Cultures to Detect and Study New Pathogenic Antibodies Involved in Autoimmune Encephalitis
Published on: June 2, 2022
Altered executive control network connectivity in anti-NMDA receptor encephalitis
Zhongqin Chen1, Jintao Zhou1, Dengchang Wu1
1Department of Neurology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Cognitive impairments in anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis patients are linked to altered executive control network (ECN) connectivity. Both static and dynamic ECN functional connectivity changes correlate with cognitive deficits.
Area of Science:
- Neuroscience
- Medical Imaging
- Psychiatry
Background:
- Anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis can cause significant cognitive deficits.
- The executive control network (ECN) is crucial for cognitive functions.
- Understanding ECN alterations in anti-NMDA receptor encephalitis is vital for characterizing cognitive impairments.
Purpose of the Study:
- To investigate if static and dynamic functional connectivity (FC) of the ECN can characterize anti-NMDA receptor encephalitis.
- To explore the correlation between ECN FC metrics and cognitive functions in patients.
Main Methods:
- 21 patients with past anti-NMDA receptor encephalitis and 23 healthy controls (HCs) underwent neuropsychological tests.
- Resting-state fMRI was used to analyze static and dynamic FC of the ECN.
- Correlation analyses examined relationships between ECN metrics and cognitive performance.
Main Results:
- Patients exhibited significant cognitive impairments compared to HCs.
- Altered static intrinsic FC and changed dynamic FC states of the ECN were observed in patients.
- Significant correlations were found between altered ECN metrics and working memory, processing speed, and executive function.
Conclusions:
- Cognitive impairments in anti-NMDA receptor encephalitis patients are associated with altered static and dynamic ECN connectivity.
- These findings enhance understanding of the pathophysiological mechanisms of cognitive dysfunction in anti-NMDA receptor encephalitis.
More Related Videos
07:20A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate NMDA Receptor in Blood
Published on: January 9, 2018
10:19High-throughput Flow Cytometry Cell-based Assay to Detect Antibodies to N-Methyl-D-aspartate Receptor or Dopamine-2 Receptor in Human Serum
Published on: November 23, 2013
