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Irritable Bowel Syndrome I: Introduction01:17

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
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The gastrointestinal elimination process involves a complex interplay of neural and hormonal mechanisms that coordinate the final waste removal from the body. This intricate operation encompasses the absorption of water and electrolytes, vital for transforming the remaining indigestible food matter into feces. The large intestine is pivotal in water and electrolyte absorption, forming feces from unabsorbed minerals, undigested food, bacteria, bile pigments, and shed epithelial cells. Essential...
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
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Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
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[Relationship between chronic constipation and brain-gut microflora axis].

Q Y Chen1, N Li1, J Jiang2

  • 1Department of Colorectal Disease, Shanghai Tenth People's Hospital, Clinical Research Center for Digestive Diseases, Tongji University, Shanghai 200072, China.

Zhonghua Wei Chang Wai Ke Za Zhi = Chinese Journal of Gastrointestinal Surgery
|December 19, 2021
PubMed
Summary
This summary is machine-generated.

The brain-gut microbiota axis significantly impacts functional gastrointestinal diseases like chronic constipation. Understanding this connection is crucial for improving diagnosis and treatment efficacy.

Keywords:
Brain-gut axisChronic constipationIntestinal flora

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Area of Science:

  • Neurogastroenterology
  • Microbiome research
  • Gastroenterology

Background:

  • Functional gastrointestinal diseases are increasingly linked to abnormal brain-gut interactions, as per ROME IV criteria.
  • Chronic constipation, a prevalent functional gastrointestinal disease, involves gut microbiota imbalance and enteric nervous system dysfunction.
  • The brain-gut microbiota axis plays a critical role in the pathophysiology of chronic constipation.

Purpose of the Study:

  • To elucidate the clinical significance of the brain-gut microbiota axis in chronic constipation.
  • To highlight the importance of integrating brain-gut microbiota axis concepts into clinical practice.
  • To address the limitations in the clinical application of the brain-gut microbiota axis for chronic constipation.

Main Methods:

  • Review of global research progress on the brain-gut microbiota axis and chronic constipation.
  • Analysis of clinical experience in managing chronic constipation.
  • Synthesis of current understanding of brain-gut-microbiota interactions in gastrointestinal disorders.

Main Results:

  • The brain-gut microbiota axis is integral to the pathogenesis of chronic constipation.
  • Current clinical applications of the brain-gut microbiota axis in chronic constipation are limited.
  • This limitation may contribute to the high incidence and poor treatment outcomes observed in chronic constipation.

Conclusions:

  • The brain-gut microbiota axis holds significant clinical importance for understanding and treating chronic constipation.
  • Integrating the brain-gut microbiota axis concept is essential for advancing the diagnosis and treatment paradigm.
  • Further research and clinical integration are needed to overcome current therapeutic limitations.