[Accuracy of VSRAD Analysis Using Scout Images: Comparison with Conventional 3D-T1WI]
Tatsuya Katayama1,2, Keita Watanabe3,4, Hidekuni Narimatsu2
1Department of Radiology, Wakamatsu Hospital of University of Occupational and Environmental Health.
Nihon Hoshasen Gijutsu Gakkai Zasshi
|December 20, 2021
Summary
Scout images show potential for Alzheimer's disease diagnosis. This fast imaging method may replace conventional 3D-T1WI in VSRAD analysis for detecting medial temporal lobe atrophy.
Area of Science:
- Neuroimaging
- Radiology
- Alzheimer's Disease Research
Context:
- The Voxel-Based Specific Regional Analysis system for Alzheimer's Disease (VSRAD) aids early Alzheimer's detection by analyzing medial temporal lobe volume loss.
- Conventional 3D T1-weighted imaging (3D-T1WI) used in VSRAD has long acquisition times.
- Rapid Scout imaging (Scout) is now available for 3D image acquisition.
Purpose:
- To evaluate the reliability of Scout images for VSRAD analysis.
- To compare VSRAD Z-scores derived from Scout versus conventional 3D-T1WI.
Summary:
- Voxel-based morphometry (VBM) revealed significant gray matter differences between Scout and 3D-T1WI.
- However, VSRAD Z-scores for medial temporal lobe atrophy showed no significant difference between the two imaging methods (p=0.41).
- Z-scores from Scout and 3D-T1WI were highly correlated (r=0.96, p<0.05).
Impact:
- Scout images demonstrate potential as a substitute for conventional 3D-T1WI in VSRAD analysis.
- This could expedite the detection of brain morphometry abnormalities in early Alzheimer's disease.
- Faster imaging may improve patient comfort and throughput in diagnostic neuroimaging.
Keywords:
Alzheimer’s diseaseSPMvoxel-based specific regional analysis system for Alzheimer’s disease (VSRAD)
