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Tranexamic acid use in pelvic and/or acetabular fracture surgery: A systematic review and meta-analysis
Henry T Shu1, Jacob D Mikula1, Andrew T Yu2
1Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD, USA.
Purpose:
The purpose of this study is to determine whether tranexamic acid (TXA) use was associated with lower rates of blood transfusion in patients undergoing pelvic and/or acetabular fracture surgery.
Methods:
Four studies were included, 3 of which were included in the pooled data analysis for a total of 308 patients.
Results:
The transfusion rate was significantly lower in the TXA group (44%) compared with the non-TXA group (57%) (P = 0.02).
Conclusion:
TXA use was associated with a significantly lower transfusion rate in patients who underwent pelvic and/or acetabular fracture surgery.
Level Of Evidence:
Level 3. Systematic review of retrospective cohort studies and prospective randomized controlled trials.
