Related Experiment Video
Updated: Oct 9, 2025

Burn Injury-Induced Pain and Depression-Like Behavior in Mice
Published on: September 29, 2021
Shame Mediates the Relationship Between Pain Invalidation and Depression
Brandon L Boring1, Kaitlyn T Walsh1, Namrata Nanavaty1
1Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX, United States.
Pain invalidation, when people’s pain is not believed, is linked to shame and depression. Shame fully explains how pain invalidation from others, especially family, contributes to depressive symptoms.
Area of Science:
- Psychology
- Clinical Psychology
- Health Psychology
Background:
- Pain is a subjective experience often met with disbelief, leading to pain invalidation.
- Pain invalidation is associated with negative mental health outcomes, including depression and reduced well-being.
- Qualitative studies suggest pain invalidation is linked to shame, characterized by self-criticism and low self-worth.
Purpose of the Study:
- To quantitatively assess the interrelationship between pain invalidation, shame, and depression.
- To investigate the mediating role of shame in the relationship between pain invalidation and depressive symptoms.
Main Methods:
- Participants reported the frequency of pain invalidation from family, friends, and medical professionals.
- Participants completed measures of internalized shame and depressive symptoms.
- Statistical analyses examined associations and mediation effects.
Main Results:
- All sources of pain invalidation positively correlated with shame and depressive symptoms.
- Shame fully mediated the link between each source of pain invalidation and depression.
- Pain invalidation from family showed the strongest association with shame and depression.
Conclusions:
- Shame is a key mechanism through which pain invalidation contributes to depression.
- Family invalidation of pain has a particularly strong impact on shame and depression.
- Findings underscore the detrimental effect of pain invalidation on mental health and highlight the importance of interpersonal support.
More Related Videos
08:15Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
Published on: June 6, 2025
09:00Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram
Published on: July 7, 2023
Related Concept Videos
Self-Discrepancy and Its Effects
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Depressive Disorders: MDD and Dysthymia
Depression: Overview
Nociception
Self-Discrepancy Theory