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Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

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Integrated Transcriptome and Multiple Activated Pathways in Endometrial Cancer.

Qi Jin^1,2, Xiaohua Jiang², Xin Du³

¹Cheeloo College of Medicine, Shandong University, Jinan, China.

Frontiers in Genetics

|December 20, 2021

Summary

Endometrial cancer (EC) gene expression is altered, with key genes showing decreased or increased activity. Understanding these molecular changes offers potential diagnostic and therapeutic targets for this growing cancer.

Keywords:

PI3K-Akt pathway TGF- β pathway endometrial cancer enrichment analysis transcriptome sequencing

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Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

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Published on: October 3, 2025

Area of Science:

Oncology
Genomics
Molecular Biology

Background:

Endometrial cancer (EC) incidence is rising globally, becoming the leading gynecologic cancer in the US.
Current treatments compromise reproductive function and survival in advanced stages.

Purpose of the Study:

To investigate aberrant gene expression profiles in endometrial cancer development.
To enhance understanding of the molecular mechanisms underlying EC pathogenesis.

Main Methods:

Next-generation transcriptome sequencing of EC and normal endometrial tissues.
Quantitative real-time PCR (RT-qPCR) for validating differentially expressed genes (DEGs).
Bioinformatic analyses including Gene Ontology (GO) and KEGG pathway analysis.

Main Results:

Identified 1153 DEGs (673 upregulated, 480 downregulated) in EC specimens.
Confirmed decreased expression of ID1, IGF1, TGF-beta, WNT4 and increased expression of GDF5, INHBA, ERBB4.
Observed enrichment of genes involved in cellular adhesion, proliferation, migration, and plasma membrane in EC.

Conclusions:

The study elucidates molecular events in EC pathogenesis.
Identified DEGs and pathways (TGF-beta, PI3K-Akt, Wnt, estrogen) represent potential diagnostic markers.
These findings may lead to novel therapeutic interventions for endometrial cancer.