Blasting Into Acute Coronary Syndrome.
Swetha R Nuthulaganti1, Fadi Kandah1, Marcos E Valentin1
1Internal Medicine, University of Florida College of Medicine, Jacksonville, USA.
Cureus
|December 20, 2021
Summary
Acute coronary syndrome (ACS) in chronic myelogenous leukemia (CML) patients can be triggered by blast crisis, leading to blood hyperviscosity. This case highlights a rare but serious cardiac complication in CML patients with existing coronary artery disease.
Area of Science:
- Cardiology
- Hematology
- Oncology
Background:
- Acute coronary syndrome (ACS) results from reduced blood flow to the heart, causing ischemia.
- Chronic myelogenous leukemia (CML) can lead to serious complications, including blast crisis.
Observation:
- A patient with CML experienced ACS precipitated by blast crisis.
- Blast crisis in CML is characterized by a high percentage of blasts in peripheral blood or extramedullary proliferation.
- Blood hyperviscosity associated with CML blast crisis can cause stroke, heart failure, and respiratory failure.
Findings:
- Leukostasis, a complication of CML blast crisis, rarely causes myocardial ischemia.
- This case presents a rare instance of ACS precipitated by CML blast crisis.
Implications:
- Highlights a potentially life-threatening cardiac complication of CML in patients with coronary artery disease.
- Emphasizes the need for optimal treatment strategies to improve outcomes in such complex cases.
- Underscores the importance of considering hematological conditions in cardiac emergencies.
Keywords:
acute coronary syndromeblast crisischonic myelogenous leukemiaclinical case reportleft heart catheterizationnon-st-elevation myocardial infarctionnstemiMore Related Videos
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