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Algorithms for optoacoustically controlled selective retina therapy (SRT).

Eric Seifert1, Jan Tode2, Amelie Pielen2

  • 1Medizinisches Laserzentrum Lübeck GmbH, Peter-Monnik-Weg 4, 23562 Lübeck, Germany.

Photoacoustics
|December 20, 2021
PubMed
Summary
This summary is machine-generated.

This study developed an optoacoustic algorithm to detect microbubble formation during Selective Retina Therapy (SRT). The algorithm accurately identifies retinal pigment epithelium (RPE) cell damage, enabling precise laser treatment control.

Keywords:
AlgorithmFeedbackLasers in medicineOphthalmologyOptoacousticsRPERetina therapySRTSelectivity

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Laser Medicine

Background:

  • Selective Retina Therapy (SRT) targets retinal pigment epithelium (RPE) cells using microbubble formation (MBF).
  • Variations in RPE pigmentation necessitate adaptive radiant exposure during SRT.
  • Ophthalmoscopically invisible RPE cell disintegration requires reliable MBF detection for treatment control.

Purpose of the Study:

  • To evaluate optoacoustically based algorithms for detecting MBF during SRT.
  • To assess the utility of MBF detection for controlling radiant exposure in SRT.

Main Methods:

  • Fifteen patients with central serous chorioretinopathy or diabetic macula edema were treated with SRT (527 nm wavelength, 1.7 µs pulse duration, 15 pulses at 100 Hz).
  • An ultrasonic transducer integrated into a contact lens detected MBF.
  • Fluorescence angiography confirmed RPE damage.

Main Results:

  • An algorithm for MBF detection as an indicator of RPE cell damage was evaluated using 4646 irradiations.
  • The developed algorithms significantly outperformed a baseline model.
  • A high sensitivity (0.96) and specificity (1) were achieved, with few false positives due to signal quality.

Conclusions:

  • The evaluated optoacoustic algorithm effectively detects MBF, indicating RPE cell damage.
  • This algorithm can guide or automate microbubble-related treatments like SRT and selective laser trabeculoplasty (SLT).