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Understanding and Managing Severe Asthma in the Context of COVID-19

Bárbara Kong-Cardoso1, Amélia Ribeiro2, Rita Aguiar1

  • 1Allergy Center, CUF Descobertas Hospital and CUF Tejo Hospital, Lisbon, Portugal.

Immunotargets and Therapy
|December 20, 2021
PubMed

Insights

Severe asthma patients face no increased risk of poor COVID-19 outcomes. It is safe to continue inhaled corticosteroids (ICS) and biologics, but oral corticosteroids (OCS) may pose risks. Further research is needed.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Immunology

Background:

  • The COVID-19 pandemic raised concerns about asthma as a risk factor for infection and adverse outcomes.
  • Management of severe asthma during the pandemic presented unique challenges and unanswered questions.

Purpose of the Study:

  • To review the literature on the management of severe asthma patients in the context of COVID-19.
  • To clarify the risks associated with COVID-19 in severe asthma patients and the safety of their treatments.

Main Methods:

  • A literature review was conducted focusing on severe asthma management during the COVID-19 pandemic.

Main Results:

  • Severe asthma patients do not appear to have an increased risk of poor COVID-19 outcomes.
  • Treatment with inhaled corticosteroids (ICS) and biologics is considered safe for asthmatics during the pandemic.
  • High-dose ICS may potentially increase COVID-19 susceptibility, and chronic oral corticosteroid (OCS) use might be linked to adverse outcomes, though evidence is not conclusive.
  • Limited data exists on triple therapy for asthma during the pandemic.

Conclusions:

  • Severe asthma patients should continue their prescribed medications, including biologics, throughout the COVID-19 pandemic.
  • Further research is required to understand the impact of asthma medications and phenotypes on COVID-19 incidence and progression.

Keywords:
COVID-19SARS-CoV-2allergybiologicscorticosteroidssevere asthma

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