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MiR-125 Family in Cardiovascular and Cerebrovascular Diseases

Yang Wang1,2, Jing Tan3, Lu Wang1,2

  • 1Department of Rehabilitation Medicine Center, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in Cell and Developmental Biology
|December 20, 2021
PubMed

Insights

The miR-125 family is crucial for cardiovascular development and disease. This microRNA family plays a role in cardiovascular diseases and holds potential for stem cell therapy.

Area of Science:

  • Molecular Biology
  • Cardiovascular Research
  • Genetics

Background:

  • Cardiovascular and cerebrovascular diseases pose significant health challenges.
  • Understanding their mechanisms and developing effective treatments remain critical.
  • The miR-125 family, comprising hsa-miR-125a, hsa-miR-125b-1, and hsa-miR-125b-2, is highly conserved across species.

Purpose of the Study:

  • To summarize the role of the miR-125 family in cardiovascular system development and maturation.
  • To elucidate the involvement of the miR-125 family in cardiovascular and cerebrovascular diseases.
  • To explore the potential of the miR-125 family in stem cell therapy.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of the miR-125 family's function in embryonic cardiovascular development.
  • Examination of miR-125's role in various cardiovascular and cerebrovascular conditions.

Main Results:

  • Lack of miR-125 leads to abnormal embryonic cardiovascular development.
  • The miR-125 family is implicated in myocardial ischemia, atherosclerosis, ischemia-reperfusion injury, ischemic stroke, and heart failure.
  • The miR-125 family shows promise in stem cell therapy applications.

Conclusions:

  • The miR-125 family is vital for cardiovascular development and disease progression.
  • Further research is needed to overcome challenges in the clinical application of miR-125.
  • miR-125 family represents a potential therapeutic target for cardiovascular and cerebrovascular diseases.

Keywords:
atherosclerosiscardiovascular and cerebrovascular diseasesischemia-reperfusionischemic strokemesenchymal stem cellmir-125myocardial ischemia

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