Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

73
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
73
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

186
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
186
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

168
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
168
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

79
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
79
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

522
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
522
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

143
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
143

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In atherosclerotic CVD, intensive vs. conventional LDL-C level targeting reduced a composite of CV events at a median 3 y.

Annals of internal medicine·2026
Same author

Proteomics analysis of empagliflozin in patients without diabetes or overt heart failure from empagliflozin and cardiac remodeling in people without diabetes CardioLink-7 randomized clinical trial.

Cardiovascular endocrinology & metabolism·2026
Same author

Projected Increases in Heat-Related Emergency Department Imaging Utilization Under Climate Change Scenarios.

Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes·2026
Same author

Objective and subjective measures of sleep quality in patients with end stage kidney disease: A cross-sectional study.

Sleep medicine·2026
Same author

Targeting Vascular Inflammation In Patients with Community-Acquired Pneumonia (TIN-CAP): protocol for a multicentre, randomised, double-blind, placebo-controlled trial.

BMJ open·2026
Same author

Relationship Between QRS Fragmentation on Electrocardiogram and Myocardial Scar Characterization on Cardiac Magnetic Resonance Imaging in Patients With Ischemic and Nonischemic Cardiomyopathy.

The American journal of cardiology·2025
Same journal

Radiation-associated bioprosthetic valve dysfunction: an initial case-control analysis.

Frontiers in cardiovascular medicine·2026
Same journal

"Pericoronary adipose tissue attenuation as a marker of global coronary inflammation rather than lesion-specific risk".

Frontiers in cardiovascular medicine·2026
Same journal

Magnetocardiography in the diagnosis of suspected ANOCA: a case series.

Frontiers in cardiovascular medicine·2026
Same journal

Bidirectional association between COPD and AF: a systematic review and meta-analysis.

Frontiers in cardiovascular medicine·2026
Same journal

Comparison of the triglyceride/high-density lipoprotein ratio, lipid profile, and glycated hemoglobin and their association with coronary artery disease in the older adult Saudi population: a case-control study.

Frontiers in cardiovascular medicine·2026
Same journal

Homocystinuria presenting with cerebral venous thrombosis: a case report highlighting progressive thrombosis.

Frontiers in cardiovascular medicine·2026
See all related articles

Related Experiment Video

Updated: Oct 9, 2025

A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation
09:12

A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation

Published on: April 27, 2019

9.7K

The Increase in Paraoxonase 1 Is Associated With Decrease in Left Ventricular Volume in Kidney Transplant Recipients.

Philip W Connelly1,2,3, Andrew T Yan4, Michelle M Nash5

  • 1Division of Endocrinology and Metabolism, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.

Frontiers in Cardiovascular Medicine
|December 20, 2021
PubMed
Summary
This summary is machine-generated.

Kidney transplantation increases Paraoxonase 1 (PON1) mass and activity, improving cardiac function by reducing left ventricular volume and NT-proBNP. This study highlights PON1

Keywords:
cardiac magnetic resonance imagingdialysiskidney transplantationleft ventricular hypertrophyparaoxonase 1

More Related Videos

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

21.1K
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

23.8K

Related Experiment Videos

Last Updated: Oct 9, 2025

A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation
09:12

A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation

Published on: April 27, 2019

9.7K
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

21.1K
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

23.8K

Area of Science:

  • Nephrology
  • Cardiology
  • Biochemistry

Background:

  • Patients on dialysis exhibit impaired cardiac function due to fluid overload and ventricular stress.
  • Restored kidney function post-transplantation improves cardiac parameters, reducing left ventricular volume.
  • Paraoxonase 1 (PON1) is linked to cardiovascular outcomes, and its changes post-transplant warrant investigation.

Purpose of the Study:

  • To investigate the association between changes in Paraoxonase 1 (PON1) and cardiac metrics after kidney transplantation.
  • To compare PON1 changes in transplant recipients versus non-recipients on dialysis to assess transplant-specific effects.

Main Methods:

  • Cardiac magnetic resonance imaging assessed left ventricular volume and mass in 38 kidney transplant recipients and 43 controls.
  • Paraoxonase 1 (PON1) was measured by arylesterase activity and mass at baseline and 12 months post-transplant.
  • Correlations were analyzed between changes in PON1, NT-proBNP, left ventricular parameters, and hemoglobin.

Main Results:

  • Kidney transplantation significantly increased both PON1 mass and activity (p < 0.0001).
  • Increased PON1 mass and activity correlated inversely with NT-proBNP changes (p = 0.0062, p = 0.0254).
  • PON1 mass changes, but not activity, inversely correlated with reduced left ventricular volume (p = 0.0146, p = 0.0114) and increased hemoglobin (p = 0.0042).

Conclusions:

  • Kidney transplantation enhances PON1 mass and activity.
  • The increase in PON1 mass is associated with improved cardiac function, indicated by reduced left ventricular volume and NT-proBNP.
  • Restored kidney function may involve a novel relationship between PON1, hemoglobin levels, and cardiovascular improvements.