Decoding gut microbiota by imaging analysis of fecal samples
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Updated: Oct 9, 2025

Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging
Published on: July 9, 2021
Chikara Furusawa1,2, Kumi Tanabe1, Chiharu Ishii3
1Center for Biosystem Dynamics Research, RIKEN, Suita, Japan.
Abstract:
The gut microbiota plays a crucial role in maintaining health. Monitoring the complex dynamics of its microbial population is, therefore, important. Here, we present a deep convolution network that can characterize the dynamic changes in the gut microbiota using low-resolution images of fecal samples. Further, we demonstrate that the microbial relative abundances, quantified via 16S rRNA amplicon sequencing, can be quantitatively predicted by the neural network. Our approach provides a simple and inexpensive method of gut microbiota analysis.

