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Related Experiment Video

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Programmable Transient Supramolecular Chiral G-quadruplex Hydrogels by a Chemically Fueled Non-equilibrium

Xiao-Qiao Xie1,2, Yunfei Zhang2, Yujia Liang2

  • 1School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, 450001, China.

Angewandte Chemie (International Ed. in English)
|December 20, 2021
PubMed
Summary

Researchers created dynamic covalent chemistry-based supramolecular hydrogels. These non-equilibrium G-quadruplex hydrogels offer programmable lifetimes and advanced properties like self-healing, paving the way for smart materials.

Keywords:
G-quadruplexesNon-equilibrium self-assemblySupramolecular chiralitySystems chemistryTransient hydrogels

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Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Chemical Engineering

Background:

  • Controlling synthetic materials like natural systems is a key challenge.
  • Dynamic covalent chemistry offers pathways for creating responsive materials.
  • G-quadruplex structures are of interest for advanced material design.

Purpose of the Study:

  • To develop a novel chemically fueled reaction network for non-equilibrium supramolecular hydrogels.
  • To achieve temporal and spatial control over hydrogel properties, including lifetime.
  • To create adaptive and interactive smart materials with enhanced functionalities.

Main Methods:

  • Utilized boronic ester-based dynamic covalent chemistry.
  • Integrated an internal pH feedback system with chemical fuels (KOH and 1,3-propanesultone).
  • Employed a combined experimental and computational approach to study self-assembly mechanisms.

Main Results:

  • Developed supramolecular chiral G-quadruplex hydrogels with programmable lifetimes (minutes to days).
  • Achieved high transparency, conductivity, injectability, and rapid self-healing properties.
  • Demonstrated a precipitate-solution-gel-precipitate cycle under non-equilibrium conditions driven by dynamic boronic ester bonds.

Conclusions:

  • The dynamic boronic ester-based strategy enables precise control over non-equilibrium self-assembly.
  • This approach provides a new method for designing next-generation adaptive and interactive smart materials.
  • The developed hydrogels exhibit a unique combination of tunable lifetimes and advanced material properties.