Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevascularized grafts with spatially organized MSC spheroids to accelerate therapeutic angiogenesis in ischemic disease.

Angiogenesis·2026
Same author

Synergistic Dual Engineering of NiO<sub>x</sub> via Ethylenediamine Chelation and γ-Ray Irradiation for Enhanced Interfacial Transport in Perovskite Solar Cells.

Small methods·2026
Same author

Perfusion-Limited Efficacy of Platelet-Rich Plasma in Adipose Tissue Grafts.

Gels (Basel, Switzerland)·2026
Same author

Non-Surgical Correction of Facial Asymmetry: A Narrative Review of Non-Surgical Modalities and Clinical Case Examples.

Journal of clinical medicine·2025
Same author

The effect of stiffness on cell behavior and drug resistance in patient-derived breast cancer organoids.

Acta biomaterialia·2025
Same author

Triple-Scale Endothelialized Tubular Networks via Hybrid Biofabrication for Scalable Vascular Tissue Engineering.

Advanced healthcare materials·2025

Related Experiment Video

Updated: Oct 9, 2025

Micropatterning and Assembly of 3D Microvessels
13:05

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

12.0K

Engineering Tissue-Specific, Multiscale Microvasculature with a Capillary Network for Prevascularized Tissue.

Jeonghyun Son1, Sung Joon Hong1, Jun Woo Lim2

  • 1Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.

Small Methods
|December 20, 2021
PubMed
Summary

Researchers developed a novel bioprinting technology to create functional, multiscale human microvasculatures. This breakthrough enables the engineering of complex, tissue-specific vascular networks for improved organ function.

Keywords:
3D bioprintingcapillary networksendothelialized channelsmultiscale microvasculatures

More Related Videos

Isolation of Murine Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Tissue Engineering
07:09

Isolation of Murine Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Tissue Engineering

Published on: April 30, 2017

12.7K
Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

16.0K

Related Experiment Videos

Last Updated: Oct 9, 2025

Micropatterning and Assembly of 3D Microvessels
13:05

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

12.0K
Isolation of Murine Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Tissue Engineering
07:09

Isolation of Murine Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Tissue Engineering

Published on: April 30, 2017

12.7K
Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

16.0K

Area of Science:

  • Biotechnology
  • Regenerative Medicine
  • Vascular Engineering

Background:

  • Engineering complex human vasculature, particularly at the capillary scale, presents significant challenges.
  • Existing technologies struggle with multiscale modeling and functional microvascular network creation.

Purpose of the Study:

  • To develop a novel technology for producing functional, multiscale microvasculatures.
  • To engineer endothelialized channels and tissue-specific capillary networks for various applications.

Main Methods:

  • Bioprinting of perfusable, endothelialized channels.
  • Induction of angiogenic sprouts into user-designed capillary networks.
  • In vitro and ex vivo functional assessments, including neovessel ingrowth and blood flow studies.

Main Results:

  • Successful production of branched and liver-lobule-like capillary networks.
  • Demonstrated functionality of channels and capillaries in vitro.
  • Successful integration with host vessels and sustained blood flow in vivo without morphological changes.

Conclusions:

  • The developed technology enables the creation of functional, multiscale, tissue-specific microvasculatures.
  • This innovation holds promise for developing highly vascularized tissues and organs on a clinically relevant scale.
  • Application in vascularized liver tissue significantly improved hepatic function.