Related Experiment Video

Updated: Oct 9, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

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Current androgen receptor antagonists under investigation for resistant prostate cancer

Maria Concetta Nigro1, Veronica Mollica1, Andrea Marchetti1

  • 1Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Expert Review of Anticancer Therapy
|December 20, 2021
PubMed
Abstract

Insights

Second-generation androgen receptor inhibitors have transformed advanced prostate cancer treatment. Ongoing research explores new strategies to overcome resistance and improve patient survival outcomes.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Advanced prostate cancer treatment relies on androgen-receptor inhibitors and chemotherapy.
  • New agents like enzalutamide, apalutamide, darolutamide, and abiraterone are clinically established.

Purpose of the Study:

  • To review the current use of androgen receptor inhibitors for castration-resistant prostate cancer.
  • To update on recent advancements, clinical trials, and the biology of castration resistance.

Main Methods:

  • Literature review of androgen receptor inhibitors in castration-resistant prostate cancer.
  • Analysis of recent progress, ongoing trials, and cancer biology.

Main Results:

  • Second-generation androgen receptor inhibitors have significantly altered advanced prostate cancer therapy.
  • Novel strategies are being investigated to combat resistance and enhance treatment efficacy.

Conclusions:

  • Androgen receptor inhibitors have revolutionized advanced prostate cancer treatment.
  • Future research focuses on overcoming resistance, optimizing drug sequencing, and combination therapies.
  • Clinical trials, biomarkers, and real-world data are crucial for improving patient outcomes.
Keywords:
Prostate cancerandrogen receptor signaling inhibitor (ARSI)androgen receptors inhibitorscastration resistant prostate cancer (CRPC)drug resistancemedical therapy

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