Related Experiment Video
Updated: Oct 9, 2025
07:34
Delivery of Antibodies into the Brain Using Focused Scanning Ultrasound
Published on: July 18, 2020
3.3K
Next-generation antibody-based therapies in neurology
Tobias Ruck1,2, Falk Nimmerjahn3, Heinz Wiendl1
1Department of Neurology with Institute of Translational Neurology, University Hospital Münster, 48149 Münster, Germany.
Brain : a Journal of Neurology
|December 20, 2021
Summary
Antibody therapies are advancing for neuroinflammatory diseases, with engineered antibody fragments improving drug delivery and efficacy for brain conditions. These treatments are increasingly successful in clinical settings.
Area of Science:
- Neuroimmunology
- Pharmacology
- Biotechnology
Background:
- Antibody-based therapeutics are established treatments for neuroinflammatory diseases.
- Antibody efficacy depends on the antigen-binding fragment (Fab) and the Fc region, which dictates immune interactions and serum half-life.
Purpose of the Study:
- To review recent advancements in antibody-based treatment modalities for neurological diseases.
- To highlight the development of technologies enhancing central nervous system (CNS) drug delivery.
Main Methods:
- Review of current literature on antibody engineering and CNS drug delivery technologies.
- Analysis of clinical trial data and successful therapeutic translations.
Main Results:
- Engineering of Fc functions allows modulation of effector functions and antibody serum half-lives.
- New technologies are improving antibody bioavailability within the CNS parenchyma.
- Several antibody-based approaches are in clinical trials or have reached clinical application.
Conclusions:
- Engineered antibody therapeutics offer significant potential for treating neurological diseases.
- Improved CNS bioavailability could expand treatment options for currently intractable brain disorders.
More Related Videos
Related Concept Videos
01:29Microorganisms in Medicine and Therapeutics
461
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
461
01:22Alzheimer's Disease: Treatment
287
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
287
01:27Tumor Immunotherapy
723
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
723