Related Experiment Video
Updated: Oct 9, 2025

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
Published on: August 30, 2024
Intestinal barrier dysfunction is associated with elevated right atrial pressure in patients with advanced
Takeshi Kitai1, Ina Nemet2, Timothy Engelman3
1Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH; Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
Abstract:
We prospectively performed serial differential sugar absorption test in 29 consecutively consented patients with advanced decompensated heart failure admitted to the heart failure intensive care unit for hemodynamically-guided therapy. We observed that intestinal barrier function was significantly impaired in our study cohort, and increased intestinal permeability was associated with elevated right atrial pressure and poorer prognosis yet without any association with systemic levels of the gut microbial metabolite, trimethylamine N-oxide (TMAO) or intestinal fatty acid binding protein that were thought to be indicative of intestinal abnormalities.
More Related Videos
08:31Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction
Published on: July 26, 2018
09:40Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
Published on: May 13, 2019
Related Concept Videos
Heart Failure III: Clinical Manifestations
Mitral Regurgitation I: Introduction
Heart Failure II: Pathophysiology
Pathophysiology of Heart Failure
Heart Failure Drugs: Diuretics
Cardiac Catheterization II: Right Heart Catheterization