Related Experiment Video
Updated: Oct 9, 2025
09:44
Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
3.1K
Shared postulations between bipolar disorder and polycystic ovary syndrome pathologies
Wenyu Dai1, Jieyu Liu2, Yan Qiu1
1National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
Progress in Neuro-Psychopharmacology & Biological Psychiatry
|December 20, 2021
Summary
Women with bipolar disorder (BD) and polycystic ovary syndrome (PCOS) share common metabolic and immune disorders. These shared conditions may explain the high prevalence of PCOS in women with BD.
Area of Science:
- Reproductive Endocrinology
- Psychiatric Disorders
- Metabolic Syndrome
Background:
- High prevalence of polycystic ovary syndrome (PCOS) observed in women with bipolar disorder (BD).
- Limited understanding of molecular mechanisms linking comorbid PCOS and BD, often attributed solely to medication effects.
Purpose of the Study:
- To review evidence linking common metabolic and immune disorders to the development of both bipolar disorder (BD) and polycystic ovary syndrome (PCOS).
Main Methods:
- Literature review focusing on shared pathophysiological pathways between BD and PCOS.
- Analysis of studies examining metabolic and immune system alterations in both conditions.
Main Results:
- Metabolic and immune disorders, including HPA axis dysfunction, chronic inflammation, gut dysbiosis, adipokine alterations, and circadian rhythm disturbances, are prevalent in both BD and PCOS.
- These shared disorders suggest a potential genetic overlap and common endophenotypes for BD and PCOS.
- Evidence supports metabolic and immune dysregulation as key factors in the increased prevalence of PCOS among women with BD.
Conclusions:
- Metabolic and immune disorders are likely responsible for the comorbidity of PCOS in the bipolar disorder (BD) population.
- Identifying shared metabolic and immune biomarkers can clarify BD's impact on reproductive endocrine function.
- This research may lead to targeted symptomatic treatments for both BD and PCOS.
Related Concept Videos
01:30Bipolar Disorder
164
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
164
01:28Obsessive-Compulsive Disorder
236
Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
236
01:27Depressive Disorders: Etiology
181
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
181
01:27Ovarian Cycle
2.1K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
2.1K
01:24Disorders of the Female Reproductive System
1.9K
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
1.9K
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
1.1K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.1K