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Updated: Oct 9, 2025

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
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The expression and function of miR-622 in a variety of tumors

Juan Lu1, Zhongyang Xie1, Zhaoying Xiao2

  • 1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|December 20, 2021
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in cancer. This review focuses on miR-622, a specific miRNA, and its significant role in various tumor development and progression, offering insights into targeted cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer presents a significant global health challenge, necessitating advanced treatment strategies.
  • Molecular targeted therapy represents a promising frontier in cancer treatment.
  • MicroRNAs (miRNAs) are crucial noncoding RNAs involved in regulating cellular processes relevant to cancer.

Purpose of the Study:

  • To review the expression patterns of miR-622 across diverse cancer types.
  • To elucidate the clinical significance and impact of miR-622 in tumorigenesis.
  • To summarize the molecular mechanisms and pathways regulated by miR-622.

Main Methods:

  • Literature review of studies investigating miR-622 expression and function in cancer.
  • Analysis of clinical data correlating miR-622 levels with tumor progression and patient outcomes.
  • Synthesis of research on miR-622's regulatory roles in cellular processes like proliferation and apoptosis.

Main Results:

  • Abnormal expression of miR-622 is implicated in the development and progression of various cancers, including liver, colorectal, breast cancer, and glioma.
  • miR-622 influences critical biological pathways, affecting cell proliferation, apoptosis, immune response, and drug resistance.
  • Expression levels and clinical effects of miR-622 vary depending on the tumor type.

Conclusions:

  • miR-622 is a significant regulator in multiple human cancers.
  • Understanding miR-622's function provides potential for novel diagnostic and therapeutic strategies in oncology.
  • Further research into miR-622 mechanisms may lead to more effective molecular targeted therapies.
Keywords:
CancerMechanismMicroRNAsMoleculesmiR-622

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