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Related Concept Videos

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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Polycyclic aromatic hydrocarbons in bone homeostasis.

Qinbin Ye1, Xiaoyu Xi1, Danping Fan2

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Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
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Polycyclic aromatic hydrocarbons (PAHs) exposure can trigger autoimmune diseases like rheumatoid arthritis and osteoporosis by disrupting bone homeostasis. This review explores PAHs

Keywords:
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Area of Science:

  • Environmental Science
  • Immunology
  • Orthopedics

Background:

  • Prolonged exposure to polycyclic aromatic hydrocarbons (PAHs) is linked to autoimmune diseases.
  • Rheumatoid arthritis (RA) and osteoporosis (OP) involve bone homeostasis imbalance, characterized by bone erosion.
  • Genetic and epigenetic factors influence bone homeostasis, but environmental factors like PAHs are increasingly significant.

Purpose of the Study:

  • To review the effects and mechanisms of PAHs on bone homeostasis.
  • To summarize recent progress on PAHs, their ligands, and receptors in bone health.
  • To discuss strategies for regulating bone balance and alleviating bone destruction caused by PAHs.

Main Methods:

  • Literature review of recent scientific progress.
  • Analysis of studies on PAHs' impact on bone homeostasis.
  • Synthesis of information on PAHs' role in autoimmune bone diseases.

Main Results:

  • PAHs significantly affect bone homeostasis, contributing to diseases like RA and OP.
  • Mechanisms involving PAHs, their ligands, and receptors in bone pathology are elucidated.
  • Evidence highlights the role of PAHs in osteoblast and osteoclast dysfunction.

Conclusions:

  • PAHs are critical environmental factors influencing bone homeostasis and autoimmune diseases.
  • Understanding PAHs' mechanisms offers potential therapeutic targets for bone destruction.
  • Further research is needed to address challenges and explore future perspectives on PAHs in bone health.